Ukusetyenziswa kweHydroxy Methionine Copper 1

Izicelo zeMveliso

1) Iinkukhu zenyama

Xa iiMMHAC (ii-chelates ze-hydroxy methionine zobhedu, i-zinc, kunye ne-manganese) zongezwe kwizidlo zeenkukhu, iziphumo zibonise ukuba—xa kuthelekiswa neeminerali zemveli ezingaphiliyo—ukubandakanywa kwe-MMHACs konyuse kakhulu ubunzima bomzimba kunye nobunzima bemisipha ye-drumstick (ithanga), kwaphucula ukugaywa kwekopolo, kwaye akuzange kube nemiphumo emibi kwimpilo ye-gizzard okanye yamathambo.

Itheyibhile 1. Ubunzima bokucubungula izidumbu (g/intaka) kunye nesifuba esinomthi kunye nesifuba esimhlophe esinomgca weenkuku ezityiswa i-inorganic kunye ne-methionine hydroxyl analogue chelated zinc, copper, kunye ne-manganese dietary treatment sat 42.

Into	I-ITM	M10	T125	I-M30	I-SEM	Ixabiso le-P
Isifuba	684	716	719	713	14.86	0.415
Ithanga	397	413	412	425	7.29	0.078
I-Drumstick	320	335	332	340	4.68	0.058
Ithanga kunye ne-drumstick	717 a	748 ab	745 ab	765 b	11.32	0.050
Iphedi yamafutha	32.3	33.1	33.4	35.5	1.59	0.546
Isibindi	68.0	67.4	66.0	71.1	2.41	0.528
Intliziyo	18.8	18.6	19.2	19.2	0.68	0.898
Izintso	9.49	10.2	10.6	10.6	0.51	0.413

Qaphela: ITM: Iiminerali ezingabonakaliyo 110 ppm Zn as ZnSO4 16 ppm Cu as CuSO4 kunye ne120 ppm Mn as MnO ngokweRoss 308 iingcebiso zesondlo;

I-M10: Ubungakanani be-40 ppm Zn 10 ppm Cu kunye ne-40 ppm Mn njenge-chelate;

I-T125: Iiminerali ezingabonakaliyo eziyi-110 ppm Zn njenge-ZnSO4 kunye ne-120 ppm Mn njenge-MnO ngokweRoss 308 izikhokelo ezine-125 ppm Cu njenge-tribasic copper chloride (TBCC);

I-M30 = 40 ppm Zn, 30 ppm Cu, kunye ne-40 ppm Mn njenge-chelate. Amaxabiso akumqolo omnye onemibhalo ephezulu eyahlukeneyo ahluka kakhulu (P < 0.05).

2) Iihagu

Uphononongo luphande ngemiphumo yokutshintsha kancinci iiminerali ezingaphiliyo ngeminerali i-methionine hydroxy analogue chelates (MMHAC) ekutyeni kweemazi zeehagu zombini kunye neehagu ezincinci. Iziphumo zibonise ukuba ukongezwa kwe-MMHAC kunciphisa ukulahleka kobunzima bomzimba kwiimazi zeehagu ezincancisayo, kwakhuthaza ukwanda kobunzima bomzimba weehagu ngosuku lwe-18, kwaphucula kakhulu amanqanaba e-acetylation yemisipha yamathambo ekuzalweni, kwaye kwanciphisa ukubonakaliswa kwezakhi zofuzo ezininzi ezinxulumene nokuvuvukala kunye nophuhliso lwemisipha. Ngokubanzi, i-MMHAC iphucule impilo yamathumbu kunye nophuhliso lwemisipha kwiimazi zeehagu ngokusebenzisa umgaqo we-epigenetic kunye nophuhliso, okwandisa amandla azo okukhula.

Itheyibhile 2 Iziphumo ezongezelelweyo ze-mineral methionine hydroxy analogue chelate ekutyeni kwemazi ekubonakalisweni kwe-mRNA ebalulekileyo enxulumene nokuvuvukala kwe-jejunal kwi-piglet encancisayo

Into	I-ITM	I-CTM	I-SEM	P- ixabiso
d 1 yokuncancisa x 10^-5
IL-8	1344	1018	178	0.193
I-MUC2	5380	5511	984	0.925
I-NF-κB (p50)	701	693	93	0.944
I-NF-κB (iphe. 105)	1991	1646	211	0.274
I-TGF-b1	Ukususela ngo-1991	1600	370	0.500
I-TNF-α	11	7	2	0.174
d 18 yokuncancisa x 10^-5
IL-8	1134	787	220	0.262
I-MUC2	5773	3871	722	0.077

Qaphela: I-Interleukin-8 (IL-8), i-mucin-2 (MUC2), i-nuclear factor-κB (NF-κB), i-transforming growth factor-1 (TGF-1), kunye ne-tumor necrosis factor-α (TNF-α)

I-ITM = imithombo eqhelekileyo ye-inorganic yeeminerali ezilandelelanayo (inqanaba lokufakwa kwe-0.2% kwizidlo)

I-CTM = 50:50 iminerali i-methionine hydroxy analogue chelate kunye neeminerali ezingaphiliyo (inqanaba lokufakwa kwe-0.2% kwizidlo)

3)Izilwanyana ezitya ezinye izilwanyana

Kwiinkomo zobisi ezincancisayo, endaweni yesiqingatha se-copper sulfatei-hydroxy methionine yobheduinyuse kakhulu uxinaniso lwe-plasma copper, iphucule ukugaywa kwe-neutral detergent fiber (NDF) kunye ne-acid detergent fiber (ADF), kwaye inyuse isivuno sobisi kunye nemveliso yobisi elungisiweyo ngamanqatha nge-4%. Ezi ziphumo zibonisa ukuba ukutshintsha i-copper sulfate nge-(HMTBA)₂-Cu ekutyeni kweenkomo zobisi yindlela efanelekileyo yokutya.

Itheyibhile 3 Imiphumo ye-methionine hydroxy Cu [(HMTBA)2-Cu] kulwakhiwo lobisi lweenkomo

Into	S	SM	M	I-SEM	Ixabiso le-P
I-DMI, kg/ngosuku	19.2	20.3	19.8	0.35	0.23
Imveliso yobisi, kg/ngosuku	28.8	33.8	31.3	1.06	0.08
Amafutha, %	3.81	3.74	3.75	0.06	0.81
Iiproteni, %	3.34	3.28	3.28	0.04	0.19
I-Lactose, %	4.48	4.35	4.43	0.05	0.08
I-SNF, %	8.63	8.84	8.63	0.05	0.33
Isivuno samafutha, kg/ngosuku	1.04	1.22	1.10	0.04	0.09
Isivuno seprotheyini, kg/ngosuku	0.92	0.92	0.90	0.03	0.72
Isivuno seLactose, kg/ngosuku	1.23	1.23	1.21	0.04	0.45
I-Urea N, mg/dL	18.39	17.70	18.83	0.45	0.19
4% FCM, kg/ngosuku	26.1	30.1	27.5	0.91	0.06

Unyango: S = Cu sulfate kuphela: 12 mg yeCu ebonelelwa yiCuSO4 ngekhilogram ye-concentrate; SM = Cu sulfate kunye (HMTBA)2-Cu: 6 mg yeCu ebonelelwa yiCuSO4, kunye nenye i-6 mg yeCu ebonelelwa yi(HMTBA)2-Cu ngekhilogram ye-concentrate; M = (HMTBA)2-Cu kuphela: 12 mg yeCu ebonelelwa yi(HMTBA)2-Cu ngekhilogram ye-concentrate.