Kwimeko yenjongo "yekhabhoni ephindwe kabini" kunye notshintsho oluluhlaza kwishishini lezilwanyana zehlabathi, iteknoloji ye-small peptide trace element iye yaba sisixhobo esiphambili sokusombulula iingxabano ezimbini "zokuphucula umgangatho kunye nokusebenza kakuhle" kunye "nokukhuselwa kwendalo" kwishishini kunye neempawu zalo zokunciphisa ukufunxwa kunye nokukhutshwa komoya ngokufanelekileyo. Ngokusetyenziswa kwe-EU "Co-additive Regulation (2024/EC)" kunye nokusasazwa kwetekhnoloji ye-blockchain, intsimi yeeminerali ezincinci eziphilayo idlula kutshintsho olukhulu ukusuka ekuqulunqweni okubonakalayo ukuya kwiimodeli zesayensi, kunye nolawulo olubanzi ukuya ekulandeleni ngokupheleleyo. Eli nqaku lihlalutya ngokucwangcisiweyo ixabiso lokusetyenziswa kwetekhnoloji ye-small peptide, lidibanisa ulwalathiso lomgaqo-nkqubo wokufuya izilwanyana, utshintsho kwimfuno yemarike, impumelelo yetekhnoloji yeepeptide ezincinci, kunye neemfuno zomgangatho, kunye nezinye iindlela eziphambili, kwaye licebisa indlela yokuguqula eluhlaza yokufuya izilwanyana ngo-2025.
1. Iindlela ezisetyenziswayo kwimigaqo-nkqubo
1) I-EU yaqalisa ngokusesikweni uMthetho woKuncitshiswa koKhupho lweZilwanyana ngoJanuwari 2025, ifuna ukuncitshiswa kwama-30% kwintsalela yesinyithi esinzima ekutyeni, kwaye ikhawulezise ukutshintshela kushishino kwizinto ezilandelelanayo zendalo. UMthetho woKutya okuLuhlaza ka-2025 ufuna ngokucacileyo ukuba ukusetyenziswa kwezinto ezilandelelanayo zendalo (ezifana ne-zinc sulfate kunye ne-copper sulfate) ekutyeni kuncitshiswe ngama-50% ngo-2030, kwaye iimveliso ze-organic chelated zikhuthazwe njengezona ziphambili.
2) UMphathiswa Wezolimo Nemicimbi Yasemaphandleni waseTshayina ukhuphe i-“Green Access Catalogue for Feed Additives”, kwaye iimveliso ezincinci ze-peptide chelated zidweliswe “njengezinye iindlela ezicetyiswayo” okokuqala.
3) UMzantsi-mpuma we-Asia: Amazwe amaninzi aqalise ngokubambisana "iSicwangciso soLimo lwe-Zero Antibiotic" ukukhuthaza izinto ezincinci ukusuka "kongezelelo lwesondlo" ukuya "kulawulo olusebenzayo" (njengokulwa noxinzelelo kunye nokuphucula amajoni omzimba).
2. Utshintsho kwimfuno yemarike
Ukwanda kwemfuno yabathengi "yenyama engenazo iintsholongwane" kubangele imfuno yezinto ezilandelelanayo ezinobuhlobo nokusingqongileyo ezinamazinga aphezulu okufunxa kwicala lezolimo. Ngokwezibalo-manani zoshishino, ubungakanani bemarike yehlabathi yezinto ezincinci ze-peptide chelated trace elements bunyuke ngama-42% unyaka nonyaka kwi-Q1 ka-2025.
Ngenxa yemozulu engaqhelekanga eMntla Melika nakuMzantsi-mpuma we-Asia, iifama zinika ingqalelo ngakumbi kwindima yezinto ezilandelelanayo ekuchaseni uxinzelelo kunye nokuphucula amandla okuzikhusela kwizilwanyana.
3. Impumelelo kwezobuchwepheshe: ukhuphiswano oluphambili lweemveliso ezincinci ze-peptide chelated trace
1) Ukufumaneka kwezinto eziphilayo ngokufanelekileyo, okuphula i-bottleneck yokufunxwa kwemveli
Iipeptides ezincinci zihluza izinto ezilandelelanayo ngokusonga ii-ion zesinyithi ngee-peptide chains ukuze zenze ii-complexes ezizinzileyo, ezifunxwa ngenkuthalo kwinkqubo yokuthutha iipeptide zamathumbu (ezifana nePepT1), ziphepha umonakalo we-asidi yesisu kunye nokuchasana kwee-ion, kwaye ukufumaneka kwazo kwi-bioavailability kuphindwe kabini ukuya kathathu kuneetyuwa ezingaphiliyo.
2) Ukusebenzisana okusebenzayo ukuphucula ukusebenza kwemveliso kwiinkalo ezahlukeneyo
Izinto ezincinci ze-peptide trace elements zilawula izityalo zamathumbu (iibhaktheriya ze-lactic acid zikhula ngokuphindwe ka-20-40), ziphucula uphuhliso lwamalungu omzimba (i-antibody titer iyanda ngokuphindwe ka-1.5), kwaye ziphucula ukufunxwa kwezondlo (umlinganiselo wokondla-kwinyama ufikelela kwi-2.35:1), ngaloo ndlela ziphucula ukusebenza kwemveliso kwiinkalo ezahlukeneyo, kubandakanya izinga lokuvelisa amaqanda (+4%) kunye nokutyeba kwemihla ngemihla (+8%).
3) Uzinzo oluqinileyo, olukhusela ngokufanelekileyo umgangatho wesondlo
Iipeptides ezincinci zenza ulungelelwaniso lwe-multi-dentate kunye nee-ion zesinyithi ngokusebenzisa i-amino, i-carboxyl kunye namanye amaqela asebenzayo ukwenza isakhiwo se-ring chelate esinamalungu amahlanu/amathandathu. Ulungelelwaniso lwe-ring lunciphisa amandla enkqubo, izithintelo ze-steric zikhusela ukuphazamiseka kwangaphandle, kwaye ukunganyamezeli kwe-charge kunciphisa ukugxothwa kwe-electrostatic, okuphucula ukuzinza kwe-chelate.
| Iziqinisi zozinzo zeeligand ezahlukeneyo ezibopha kwii-ion ze-copper phantsi kweemeko ezifanayo ze-physiological | |
| Uzinzo lweLigand oluqhubekayo 1,2 | Uzinzo lweLigand oluqhubekayo 1,2 |
| I-Log10K[ML] | I-Log10K[ML] |
| Ii-Amino Acids | I-Tripeptide |
| IGlycine 8.20 | I-Glycine-Glycine-Glycine 5.13 |
| ILysine 7.65 | I-Glycine-Glycine-Histidine 7.55 |
| I-Methionine 7.85 | I-Glycine Histidine Glycine 9.25 |
| I-Histidine 10.6 | I-Glycine Histidine Lysine 16.44 |
| I-asidi ye-aspartic 8.57 | I-Gly-Gly-Tyr 10.01 |
| I-Dipeptide | I-Tetrapeptide |
| I-Glycine-Glycine 5.62 | I-Phenylalanine-Alanine-Alanine-Lysine 9.55 |
| I-Glycine-Lysine 11.6 | I-Alanine-Glycine-Glycine-Histidine 8.43 |
| I-Tyrosine-Lysine 13.42 | Isicatshulwa: 1. IziQinisekiso zoZinzo Ukumisela kunye nokusetyenziswa, uPeter Gans. 2. IziQinisekiso zoZinzo ezikhethiweyo ngokweCitric zezakhiwo zesinyithi, iDatabase ye-NIST 46. |
| I-Histidine-methionine 8.55 | |
| I-Alanine-Lysine 12.13 | |
| I-Histidine-serine 8.54 | |
Umfanekiso 1 Iziqinisi zozinzo zeeligand ezahlukeneyo ezibopha kwiCu2+
Imithombo yeeminerali ezibotshelelwe kancinci inamathuba amaninzi okufumana ii-redox reactions kunye neevithamini, iioyile, ii-enzymes kunye nee-antioxidants, nto leyo echaphazela ixabiso elifanelekileyo lezondlo zokutya. Nangona kunjalo, esi siphumo sinokuncitshiswa ngokukhetha ngononophelo i-trace element enozinzo oluphezulu kunye ne-response ephantsi ngeevithamini.
Ukuthatha iivithamini njengomzekelo, uConcarr et al. (2021a) bafunde ukuzinza kwevithamini E emva kokugcinwa kwexesha elifutshane kwe-inorganic sulfate okanye iintlobo ezahlukeneyo zee-premixes ze-organic mineral. Ababhali bafumanise ukuba umthombo wezinto ezilandelelanayo uchaphazele kakhulu ukuzinza kwevithamini E, kwaye i-premix esebenzisa i-organic glycinate yayinokulahleka okuphezulu kwevithamini kwe-31.9%, kulandele i-premix esebenzisa i-amino acid complexes, eyayiyi-25.7%. Akukho mahluko ubalulekileyo ekulahlekelweni kokuzinza kwevithamini E kwi-premix equlethe iityuwa zeproteni xa kuthelekiswa neqela lolawulo.
Ngokufanayo, izinga lokugcina iivithamini kwi-organic trace element chelates ngendlela yeepeptides ezincinci (ezibizwa ngokuba yi-x-peptide multi-minerals) ziphezulu kakhulu kunezinye imithombo yezimbiwa (Umfanekiso 2). (Qaphela: Ii-organic multi-minerals kuMfanekiso 2 zii-glycine series multi-minerals).
Umfanekiso 2 Impembelelo yee-premixes ezivela kwimithombo eyahlukeneyo kwizinga lokugcina iivithamini
1) Ukunciphisa ungcoliseko kunye nokukhutshwa komoya ukuze kusonjululwe iingxaki zolawulo lokusingqongileyo
4. Iimfuno zoMgangatho: ukubekwa emgangathweni kunye nokuthobela imithetho: ukufumana indawo ephezulu yokhuphiswano lwamazwe ngamazwe
1) Ukuziqhelanisa nemigaqo emitsha ye-EU: ukuhlangabezana neemfuno zemigaqo ka-2024/EC kunye nokubonelela ngeemephu zendlela ye-metabolic
2) Yenza izalathisi eziyimfuneko kunye nesantya se-chelation yeleyibhile, i-dissociation constant, kunye ne-intestinal stability parameters
3) Khuthaza iteknoloji yokugcina ubungqina be-blockchain, iiparameter zenkqubo yokulayisha kunye neengxelo zovavanyo kuyo yonke inkqubo
Itekhnoloji ye-small peptide trace element ayisiyonto nje yokutshintsha izongezo zokutya, kodwa ikwayinjini ephambili yotshintsho oluluhlaza kwishishini lemfuyo. Ngowama-2025, ngokukhawuleziswa kokwenziwa kwedijithali, ubungakanani kunye nokwenziwa kwamazwe ngamazwe, le teknoloji iya kuyila kwakhona ukhuphiswano lweshishini ngeendlela ezintathu "zokuphucula ukusebenza kakuhle-ukukhuselwa kwendalo kunye nokunciphisa ukukhutshwa komoya-ixabiso elongeziweyo". Kwixesha elizayo, kuyimfuneko ukuqinisa ngakumbi intsebenziswano phakathi kweshishini, i-academia kunye nophando, ukukhuthaza ukwenziwa kwamazwe ngamazwe kwemigangatho yobugcisa, kunye nokwenza isisombululo saseTshayina sibe ngumlinganiselo wophuhliso oluzinzileyo lwemfuyo yehlabathi.
Unxibelelwano lweendaba:
UElaine Xu
I-SUSTAR
Email: elaine@sustarfeed.com
Iselfowuni/iWhatsApp: +86 18880477902
Ixesha leposi: Epreli-30-2025
