Iindaba - Ukusetyenziswa kwe-Zinc Oxid eqhelekileyo kwi-Antidiarrhea yamantshontsho

Mna.

I-zinc oxide, eyaziwa ngokuba yi-zinc white, yi-amphoterici-zinc oxideenganyibilikiyo emanzini kodwa inyibilikayo kwi-asidi nakwi-alkali enamandla. Ifomyula yayo yekhemikhali yi-ZnO, ubunzima be-molecular yi-81.37, inombolo ye-CAS yi-1314-13-2, indawo yokunyibilika yi-1975℃ (ukubola), indawo yokubila yi-2360℃, kwaye ayinyibilikiyo emanzini. Isetyenziswa kakhulu kwiindawo ezingaphezu kwama-20 ezifana neeplastiki, iimveliso ze-silicate, irabha yokwenziwa, izinto zokuthambisa, iipeyinti kunye neengubo, amafutha okuthambisa, izincamathelisi, ukutya, iibhetri, izinto ezithintela ilangatye,njl. njl.

Umfanekiso 1I-zinc oxideisampuli

III. Imingeni yorhudo kumantshontsho eehagu ancancisiweyo kunye nexabiso leklinikhii-zinc oxide

Ukulumla umntwana sisiganeko esinzima kakhulu ebomini behagu. Iingxaki ezinje ngokusebenza okubuthathaka kokuthintela amathumbu, ukukhutshwa okunganelanga kwee-enzymes zokugaya ukutya, kunye nokungalingani kwezityalo kudla ngokukhokelela kwisifo sohudo emva kokulumla umntwana (PWD), esisongela kakhulu ukukhula kunye neenzuzo zokuzalela kwamantshontsho.i-zinc oxideKufunyaniswe ukuba inemiphumo ebalulekileyo yokulwa norhudo ngeminyaka yoo-1980, ibe “ngumgangatho wegolide” kwishishini lemfuyo lehlabathi ukujongana ne-PWD. Izifundo zibonise ukuba ukongeza i-2500-3000 mg/kgi-zinc oxideinokunciphisa izinga lorhudo ngama-40%-60%, ngelixa inyusa ukunyuka kobunzima bemihla ngemihla nge-10%-15%. Ixabiso layo eliphambili lisekuzinziseni ngokukhawuleza imeko yamathumbu ngokusebenzisa iindlela ezininzi, ukubonelela ngokhuseleko olubalulekileyo lwexesha lokutshintsha kwamantshontsho eehagu.

Imingeni yorhudo kumantshontsho eehagu akhunyulweyo kunye nexabiso leklinikhi le-zinc oxide

IV.Indlela yokusebenza kwei-zinc oxidengokuchasene norhudo

1)Ukuqinisa umqobo womzimba wamathumbu

I-zinc oxideIkhuthaza ukwanda kweeseli ze-epithelial zamathumbu, inyusa kakhulu umlinganiselo wokuphakama kwe-intestinal villus ukuya kubunzulu be-crypt, iphucula indawo yomphezulu yokufunxwa kwezondlo, kwaye ngaxeshanye inyusa ukubonakaliswa kweeproteni eziqinileyo (Occludin, ZO-1), inciphisa ukungena kwe-intestinal mucosal, kwaye ithintele ukuhlasela kwezifo ezibangelwa ziintsholongwane. Ikhusela umsebenzi wokuthintela i-intestinal mucosal, iphucula amandla okulwa neentsholongwane eehagu, kwaye inciphisa urhudo.

Umfanekiso 2Iziphumo zeedosi ezahlukeneyo zei-zinc oxidemalunga nokwakheka kwamathumbu amantshontsho eehagu

Umfanekiso 3 Imiphumo yeedosi ezahlukeneyo ze-zinc oxide kwiiproteni ze-intestinal tight junction kumantshontsho eehagu

Umfanekiso 3Iziphumo zeedosi ezahlukeneyo zei-zinc oxidekwiiproteni ze-intestinal tight junction kumantshontsho eehagu

2)Ukulawula ibhalansi yeentsholongwane zamathumbu

I-zinc oxideivelisa ii-free radicals ze-hydrogen peroxide emathunjini, nto leyo ebalulekileyo kumsebenzi wokulwa neentsholongwanei-zinc oxideIdosi ephezului-zinc oxideithintela ngokuthe ngqo ukwanda kweebhaktheriya ezibangela izifo ezifana ne-Escherichia coli kunye ne-Salmonella ngokukhupha iintlobo ze-oxygen ezisabelayo (i-ROS), ngelixa ikhuthaza ukuhlanganiswa kweebhaktheriya eziluncedo ezifana ne-Lactobacillus.

Umfanekiso 4Iziphumo zokutyai-zinc oxidekwiintsholongwane ze-cecal kumantshontsho eehagu

3) I-zinc eninzi ikhuthaza ukukhula kwamantshontsho eehagu

Uxinzelelo lokulunyulwa kwesisu lubangela ukwehla kwe-30% ekugayweni kokutya, kwaye ukugaywa kwezondlo kumantshontsho eehagu ancancisiweyo kuncipha ngakumbi xa ekwimeko yorhudo. Izifundo zibonisileloo ntoukongeza iidosi eziphezulu zei-zinc oxideukutya okunokunyusa amanqanaba e-zinc egazini, ukulawula ngakumbi ukukhutshwa kweepeptides zamathumbu engqondo kunye neehomoni zendlalakunyekhuthaza amantshontsho eehagu ukuba atye. Ngaxeshanye, ukwanda komxholo we-zinc egaziniikaniikhuthaza ngokufanelekileyo ukwenziwa kunye nokusebenza kwee-enzymes zokugaya ukutya, ukuphucula ukugaywa kwezakhamzimbakunyekwandisa ukutyeba kwemihla ngemihla kwamantshontsho eehagu.

Umfanekiso 5Iziphumo ze-zinc oxide ekusebenzeni kakuhle kweehagu ezilunyulweyo

IV. Isicwangciso seSicelo seSayensi kunye naMacebiso okuThintela

1. Idosi echanekileyo kunye nomjikelo wokusetyenziswa

Nangona kuchazwe ukuba i-zinc ephezulu (1600-2500 mg/kg)i-zinc oxide) ifidi ingasetyenziswa kuphela kwi"kwiiveki ezimbini zokuqala emva kokulunyulwa", iifama zeehagu ezininzi ziyandisa ukusetyenziswa kokutya okunezinc eninzi kangangeeveki ezi-2 ukuya kwezi-8. Ngeli xesha, ezinye iifama zeehagu ziya kuba namava"iziphumo ebezingalindelekanga eziphezulu ze-zinc", ezidla ngokubonakala njengeenwele ezinde neziqinileyo kunye nolusu olufipheleyo.

2. Khethai-zinc oxidengozinzo oluphezulu ukuphucula isiphumo semveliso

Ukufumaneka kwezinto eziphilayoi-zinc oxideeziveliswa yinkqubo yokumanzi ziphezulu kakhulu kunezoi-zinc oxideiveliswe yinkqubo ethe ngqo. Ke ngoko, xa ukhethai-zinc oxideiimveliso, inkqubo yemveliso yayo nayo kufuneka iqwalaselwe.

5. Iindlela zoshishino kunye neNkangeleko yoBugcisa obuNye

Nangona i-EU inciphise ubungakanani be-zinc eyongeziweyo kwi-150 mg/kg, imisebenzi yasekhaya ibonisa ukuba ukutshintshwa ngokupheleleyo kwe-zinc ephezulu kusajongene nemiqobo yobuchwephesha. Ezinye iindlela ezikhoyo ezifana ne-nanoi-zinc oxide(300 mg/kg) kunye ne-basic zinc chloride (1200 mg/kg) zinokunciphisa umthamo, kodwa ixabiso lazo liphezulu, uzinzo lwenkqubo alwanelanga, kwaye ukhuseleko lwexesha elide lusafuna ukuqinisekiswa. Ke ngoko,eqhelekileyoi-zinc oxideiselukhetho olufanelekileyo kwiifama ezincinci neziphakathi ukulinganisela iindleko kunye nesiphumo.